Bug reports are already starting to come in about the newly released Madden NFL 07. However EA have responded and apparently a patch is in the works.
The first issue that some players are reporting is Hall of Fame players showing up in the game franchise mode as selectable. However EA have said that this is working as it should, and that you can draft such players into your franchise once you have unlocked them.
The second bug is that players do not seem to be fatiguing, however EA have responded to this one also (via 1UP), saying that it just seems they are not fatiguing from the game interface:
That's actually not the case. The UI isn't registering it... You fatigue at a lower pace than in the past, but it isn't reflected in the UI. [It's] Something we're addressing and fixing right now.
Apparently a patch is on its way and gamers will be able to detect tired players and manage their teams as necessary.